At a glance
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5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females
In Brief
A Phase 4 clinical trial evaluating 5-hydroxytryptophan and Creatine monohydrate for Major Depressive Disorder. Completed, enrolled 15 participants across 1 site.
Detailed Summary
The investigators hypothesize that the administration of two widely available, naturally occurring dietary supplements, 5 hydroxytryptophan and creatine monohydrate, will reduce the severity of depression in individuals exposed to chronic hypoxia by living at altitude. The purpose of this study is to determine if 8 weeks of dietary augmentation with oral 5 g creatine daily and 100 mg 5-HTP twice daily reduces hypoxia-related depressive symptoms measured by the 17-item Hamilton Depression Rating Scale (HAM-D) in women with SSRI or SNRI-resistant depression.