At a glance
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Randomized Clinical Trial on Preventing and Arresting Dental Root Surface Caries Using Silver Diamine Fluoride Solution in Community-dwelling Older Adults
In Brief
A Phase 3 clinical trial evaluating silver diammine fluoride, Water as placebo, and 1 other intervention for Dental Caries. Completed, enrolled 323 participants across 1 site.
Detailed Summary
This study is a randomized clinical trial lasting for 30 months. A total of 300 subjects will be recruited from social centres for elders located in different districts in Hong Kong. Baseline clinical examination will be conducted by a single calibrated examiner in the social centres using an intra-oral LED light, mouth mirrors and probes. Subjects will be randomly allocated into the three study groups and receive interventions accordingly. Follow-up examinations at 6-month intervals will be carried out to assess the clinical outcomes, i.e. whether new root caries has developed and whether the active root caries found at baseline have become arrested (remineralized and hardened) or not. Photographs of the arrested lesions will be taken to assess their colour. Results of this study will provide the much needed evidence to guide the dental professionals in Hong Kong and worldwide in deciding on the most appropriate intervention for the prevention and treatment of this common dental disease of the older adults.
Study Details
Timeline
Interventions
topical application of the SDF solution onto tooth root surfaces
topical application of water as a placebo in the control arm
topical application of SDF solution followed by KI solution onto tooth root surfaces