At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Does Dapagliflozin Augment The Favorable Adaptation To Endurance Exercise Training?
In Brief
A Phase 2 clinical trial evaluating Dapagliflozin and Placebo for Physical Activity. Completed, enrolled 37 participants across 1 site.
Detailed Summary
Exercise is frequently prescribed as a favorable lifestyle intervention to prevent/reverse type 2 diabetes. It is also prescribed in addition to concurrent pharmacological treatment, such as metformin. Recent data (animal and human) suggest that metformin may attenuate the favorable benefits of exercise training. In light of the physiological mechanism of Dapagliflozin (sodium-glucose co-transporter 2 (SGLT2) inhibition), one might speculate that rather than inhibit, it will augment the favorable adaptations to exercise training.
Study Details
Timeline
Interventions
Dapagliflozin tablets, 5 mg, one per day for the first 14 days, increase to two per day for 70 days.
Matching placebo for Dapagliflozin 5 mg, one per day for the first 14 days, increase to two per day for 70 days.