CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 807 enrolled
Drug / intervention
Positive Cognitive Bias Modification - Interpretation +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02382003
NCT02382003Phase 2Completed

Testing Target Engagement and Effectiveness of Web-based Interpretation Training For Anxiety

University of Virginia·interventional·Posted Mar 6, 2015·Updated Feb 20, 2025

In Brief

A Phase 2 clinical trial evaluating Positive Cognitive Bias Modification - Interpretation, 50/50 Cognitive Bias Modification - Interpretation, and 2 other interventions for Anxiety. Completed, enrolled 807 participants across 1 site.

Detailed Summary

The study aims to develop a web-based Cognitive Bias Modification infrastructure to train interpretations, and evaluate the usability, acceptability, and feasibility of the program to reduce anxiety symptoms.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnxiety
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedMar 6, 2015
Enrollment StartApr 1, 2016
Primary CompletionJan 1, 2019
Study CompletionMar 1, 2019
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 11.3 years ago

Interventions

Positive Cognitive Bias Modification - Interpretationbehavioral

Training involves presenting participants with brief scenarios that introduce an ambiguous potential threat. Critically, the ambiguity regarding how the situation is resolved remains until the last word of the scenario, which is presented as a word fragment that the participant must solve, which will then assign a benign (rather than threatening) meaning to the scenario.

50/50 Cognitive Bias Modification - Interpretationbehavioral

This condition follows the same design and content as the Positive Training conditions, except the word fragments differ; rather than consistently resolving the scenario in a positive direction, half of the scenarios will end with a negative (anxiety-congruent) word fragment, and half will end with a positive word fragment.

Anxious Imagery Primebehavioral

We will test whether priming anxious concerns and feared negative outcomes on the web via the addition of a guided anxious imagery prime at the start of each session will enhance effects.

Neutral Imagery Primebehavioral

At the start of each session, participants will complete a neutral control imagery exercise where they do a guided imagery exercise imagining upcoming mundane tasks, like brushing one's teeth.