CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 150 enrolled
Drug / intervention
Prophylactic cranial irradiation (PCI) +1 moreradiation
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02397733
NCT02397733N/ACompleted
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Phase III Trial Evaluating Memory Preservation of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance in Small Cell LUNG Cancer (PREMER-TRIAL)

Grupo de Investigación Clínica en Oncología Radioterapia·interventional·Posted Mar 25, 2015·Updated Aug 2, 2021

In Brief

A clinical study evaluating Prophylactic cranial irradiation (PCI) and Hippocampal avoidance PCI for Small Cell Lung Carcinoma. Completed, enrolled 150 participants across 1 site.

Detailed Summary

The main objective of this study i sto evaluate the impact of prophylactic cranial irradiation (PCI) with hippocampal avoidance in the neurocognitive function and quality of life of small cell lung cancer patients. In addition, the trial assesses the potential changes in hippocampal volumetry due to cranial irradiation using magnetic resonance imaging.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSmall Cell Lung Carcinoma
CountriesSpain
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedMar 25, 2015
Enrollment StartSep 1, 2014
Primary CompletionOct 1, 2019
Study CompletionDec 1, 2020
TodayJul 2, 2026
Enrollment to primary: 5.1 yearsPosted 11.3 years ago

Interventions

Prophylactic cranial irradiation (PCI)radiation

Prophylactic cranial irradiation (PCI): 25 Gy in 10 daily fractions, five times a week

Hippocampal avoidance PCIradiation

Hippocampal avoidance prophylactic cranial irradiation 25 Gy in 10 daily fractions, five times a week