At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phase I Trial of MK-3475 and Concurrent Chemo/Radiation for the Elimination of Small Cell Lung Cancer
In Brief
A Phase 1 clinical trial evaluating Carboplatin, Cisplatin, and 4 other interventions for Extensive Stage Small Cell Lung Carcinoma and 2 related conditions. Completed, enrolled 83 participants across 1 site.
Detailed Summary
This phase I trial studies the side effects and best dose of pembrolizumab when given together with chemoradiotherapy or radiation therapy in treating patients with small cell lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill cancer cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more cancer cells. Giving pembrolizumab with chemoradiotherapy or radiation therapy may be a better treatment for small cell lung cancer.
Study Details
Timeline
Interventions
Given IV
Given IV
Given IV
Correlative studies
Given IV
Undergo radiation therapy