At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Medium-chain Triglycerides Emulsification on Ketogenesis and Adverse Effects in Human Adults
In Brief
A clinical study evaluating MCT oil 10g, MCT homogenate 10g, and 5 other interventions for Healthy. Completed, enrolled 10 participants.
Detailed Summary
Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates. Medium-chain triglycerides (MCT) are rapidly beta-oxidized and are ketogenic. Large doses of MCT oil are linked to gastro-intestinal side effects due to incomplete absorption so the investigators examined whether homogenisation into a skim milk matrix (MCT-H) would both improve ketogenesis and reduce side-effects compared to MCT taken without homogenisation into a matrix (bulk MCT \[MCT-B\]). Hypotheses: (i) MCT-H will be better absorbed compared to MCT-B, so MCT-H will result in higher ketonemia and lower side effects in healthy adults. (ii) The effects of MCT-B and MCT-H on ketogenesis will be dose-dependent.
Study Details
Timeline
Interventions
10 g of pure MCT oil mixed with skim milk in a standardized breakfast
10g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast
vehicule (skim milk) with a standardized breakfast
20g of pure MCT oil mixed with skim milk in a standardized breakfast
20g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast
30g of 100% pure MCT oil mixed with skim milk in a standardized breakfast
30g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast