At a glance
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Echocardiographic Detection of Extravascular Lung Water Increase During Weaning From Mechanical Ventilation
In Brief
A clinical study evaluating Monitoring of pulmonary oedema induced by weaning from mechanical ventilation for Ventilator Weaning. Completed, enrolled 30 participants across 1 site.
Detailed Summary
Switching from positive airway pressure ventilation to spontaneous ventilation during weaning from mechanical ventilation, pulmonary edema may occur and in this case, doppler echocardiographic (U/S) indices of cardiac dysfunction correlates with the concentration of fluid in interstitial space. Forty consecutive mechanically ventilated critical ill patients who fulfill criteria for weaning from mechanical ventilation, will be included in this study. All patients will be evaluated daily and when the patients fulfill weaning criteria them they will undergo a 2-hour spontaneous breathing trial (SBT) through a T-piece. Before and after SBT cardiopulmonary function will be assessed by thermodilution and echocardiography. In patients with preserved LV systolic function, an echocardiographic index of diastolic dysfunction (E/Em ratio) before preforming SBT may identify high risk patients for increasing extravascular water in weaning. In addition, the investigators expect to find positive correlations (p\<0.05) between pulmonary extravascular lung water and echocardiographic indices (such as E/Em ratio) during SBT.