CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 730 enrolled
Drug / intervention
Empagliflozin +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02414958
NCT02414958Phase 3Completed

A Phase III, Randomised, Double Blind, Placebo-controlled, Parallel Group, Efficacy, Safety and Tolerability Trial of Once Daily, Oral Doses of Empagliflozin as Adjunctive to inSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)

Boehringer Ingelheim·interventional·Posted Apr 13, 2015·Updated Jan 3, 2019

In Brief

A Phase 3 clinical trial evaluating Empagliflozin and Placebo for Diabetes Mellitus, Type 1. Completed, enrolled 730 participants across 131 sites in 17 countries.

Detailed Summary

Comparison of 2 doses of empagliflozin vs placebo in patients already using either an insulin regimen of multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII). Randomisation to 3 treatments arms (equal assignment) following a screening period, an optimisation period and a run-in period. 52 week double-blind treatment period, and 3 week follow-up period.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Austria, Belgium, Canada, Czechia, Denmark, Finland, France, Germany, Netherlands, Norway, Poland, Spain, Sweden, Taiwan, United Kingdom, United States

Timeline

Phase 3CompletedFinished
201520162017201820192020202120222023202420252026
First PostedApr 13, 2015
Enrollment StartJun 30, 2015
Primary CompletionApr 20, 2017
Study CompletionOct 23, 2017
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 11.2 years ago

Interventions

Empagliflozindrug

Empagliflozindrug

Placebodrug