At a glance
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The IMPACT Study: Inflammatory Responses, Mood and Physical Fitness After Cancer Treatment
In Brief
A Early Phase 1 clinical trial evaluating typhoid vaccine and Placebo for Cognitive Side Effects of Cancer Therapy and 7 related conditions. Completed, enrolled 172 participants across 1 site.
Detailed Summary
This randomized clinical trial uses an inactive typhoid vaccine to briefly stimulate an immune response in patients with stage I-IIIA breast cancer who received primary cancer treatment and studies whether patients' fitness levels affect how their bodies handle a challenge to their immune system. A vaccine is a substance or group of substances meant to cause the immune system to respond to a tumor or to microorganisms such as bacteria or viruses. Immune responses may cause excess inflammation in the body and behavioral changes, such as depression, fatigue, pain, and problems with thinking and reasoning. Studying immune responses in patients with breast cancer who have undergone primary cancer treatment may help doctors learn whether physical fitness can protect the body from effects of immune system stress and whether it may be able to reduce health problems in patients with breast cancer.
Study Details
Timeline
Interventions
Given IM
Given IM