At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 31 enrolled
Drug / intervention
Prucalopride +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus
In Brief
A Phase 4 clinical trial evaluating Vagus stimulation, Sham stimulation, and 2 other interventions for Postoperative Ileus. Completed, enrolled 31 participants across 1 site.
Detailed Summary
Hypothesis: Prucalopride can mimic electrical stimulation of the abdominal vagus nerve and has an anti-inflammatory effect. Aims: In the present pilot study, the investigators want to evaluate the anti-inflammatory effect of prucalopride. The following aims are formulated: 1. to show that prucalopride has a similar inflammatory effect as abdominal vagus nerve stimulation (VNS) 2. to evaluate whether prucalopride leads to accelerated post-operative recovery
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Ileus
CountriesBelgium
CollaboratorsUniversitaire Ziekenhuizen KU Leuven
Timeline
Phase 4CompletedFinished
201520162017201820192020202120222023202420252026
Enrollment StartJul 2014
First PostedApr 2015
Primary CompletionFeb 2016
TodayJul 2026
First PostedApr 24, 2015
Enrollment StartJul 1, 2014
Primary CompletionFeb 27, 2016
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 11.2 years ago
Interventions
Vagus stimulationprocedure
Sham stimulationprocedure
Prucalopridedrug
Placebodrug