At a glance
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Phase 2 Study of Preoperative Chemotherapy With Abraxane and Gemcitabine Followed by Chemoradiation for Borderline Resectable or Node-Positive Pancreatic Cancer
In Brief
A Phase 2 clinical trial evaluating Fluorouracil, Gemcitabine, and 5 other interventions for Pancreatic Adenocarcinoma and Resectable Pancreatic Carcinoma. Completed, enrolled 20 participants across 1 site.
Detailed Summary
This phase II trial studies how well nab-paclitaxel and gemcitabine hydrochloride followed by radiation therapy before surgery work in treating patients with pancreatic cancer that can be removed by surgery. Chemotherapy drugs, such as nab-paclitaxel and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving nab-paclitaxel, gemcitabine hydrochloride, and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
Study Details
Timeline
Interventions
Given IV
Given IV
Undergo IG-IMRT
Undergo IG-IMRT
Correlative studies
Given IV
Undergo surgery