CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 300 enrolled
Drug / intervention
standard dose prescription +1 moreradiation
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02442375
NCT02442375Phase 3Completed
CompareCT.gov

Uniform FDG-PET Guided GRAdient Dose prEscription to Reduce Late Radiation Toxicity (UPGRADE-RT): a Randomised Controlled Trial With Dose Reduction to the Elective Neck in Head and Neck Squamous Cell Carcinoma

Radboud University Medical Center·interventional·Posted May 13, 2015·Updated Nov 18, 2025

In Brief

A Phase 3 clinical trial evaluating standard dose prescription and FDG-PET guided gradient dose prescription for Head and Neck Neoplasms and Carcinoma, Squamous Cell. Completed, enrolled 300 participants across 5 sites.

Detailed Summary

The objective of the UPGRADE-RT trial is to investigate whether de-escalation of elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life after treatment whilst the recurrence rate in electively irradiated lymph nodes should not be compromised. The full study protocol can be found here: https://doi.org/10.1200/jco-24-02194

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHead and Neck Neoplasms, Carcinoma, Squamous Cell
CountriesNetherlands
CollaboratorsUMC Utrecht, Amsterdam UMC, location VUmc, Maastro Clinic, The Netherlands, Radiotherapiegroep

Timeline

Phase 3CompletedFinished
20162017201820192020202120222023202420252026
First PostedMay 13, 2015
Enrollment StartJun 1, 2016
Primary CompletionJul 3, 2024
TodayJul 2, 2026
Enrollment to primary: 8.1 yearsPosted 11.1 years ago

Interventions

standard dose prescriptionradiation

* standard elective dose * no intermediate dose-level * visual interpretation of FDG-PET-scan

FDG-PET guided gradient dose prescriptionradiation

* de-escalation of elective dose * intermediate dose-level * standardized methods to evaluate FDG-PET-scan