CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 575 enrolled
Drug / intervention
PSV ventilation strategy +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02447692
NCT02447692N/ACompleted
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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·interventional·Posted May 19, 2015·Updated May 22, 2025

In Brief

A clinical study evaluating PSV ventilation strategy and PAV+ ventilation strategy for Critically Ill and Acute Respiratory Failure. Completed, enrolled 575 participants across 22 sites in 7 countries.

Detailed Summary

For adult patients with acute respiratory failure requiring invasive mechanical ventilation, does a ventilation strategy using proportional assist ventilation with load-adjustable gain factors (PAV+) result in a shorter duration of time spent on mechanical ventilation than a ventilation strategy using pressure support ventilation (PSV)?

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCritically Ill, Acute Respiratory Failure
CountriesArgentina, Canada, France, Greece, Italy, Saudi Arabia, Spain
CollaboratorsCanadian Institutes of Health Research (CIHR), Medtronic, Canadian Critical Care Trials Group

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedMay 19, 2015
Enrollment StartSep 14, 2016
Primary CompletionJul 16, 2024
TodayJul 2, 2026
Enrollment to primary: 7.8 yearsPosted 11.1 years ago

Interventions

PSV ventilation strategyother

An algorithm for adjusting the level of pressure support according to usual clinical parameters; patients not tolerating PSV will be switched to Assist/Control mode according to predefined criteria

PAV+ ventilation strategyother

An algorithm for adjusting the level of support (gain) to maintain a predefined range of respiratory muscle pressure; patients not tolerating PAV+ (Puritan Bennett™ 840 or 980 ventilator) will be switched to Assist/Control mode according to predefined criteria