At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluation of the Prophylactic Antimalarial Activity of a Single Dose of DSM265 in Non-immune Healthy Adult Volunteers by Controlled Human Malaria Infection With PfSPZ Challenge
In Brief
A Phase 1 clinical trial evaluating DSM265 400mg, Placebo to DSM265 400 mg, and 2 other interventions for Plasmodium Falciparum, Malaria. Completed, enrolled 22 participants across 1 site.
Detailed Summary
Study to evaluate the efficacy of DSM265 as a causal prophylactic in a standardized and validated Human Challenge model using direct venous inoculation of aseptic, purified, cryopreserved, vialed Plasmodium falciparum sporozoites.
Study Details
Timeline
Interventions
DSM265 400mg, single oral administration in a fed state
Placebo to DSM265 400mg, single oral administration in a fed state
IV Plasmodium falciparum sporozoites (3200) by direct venous inoculation
250 mg atovaquone, 100 mg proguanil hydrochloride