At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics
In Brief
An observational study evaluating Observation for Severe Malaria. Completed, enrolled 840 participants across 1 site.
Detailed Summary
* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. * Despite treatment between 10-30% of patients with severe malaria die. * Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood. * Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.