At a glance
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A Phase III Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma
In Brief
A Phase 3 clinical trial evaluating Carboplatin and Vincristine and Carboplatin for Low Grade Glioma. Active but no longer recruiting, targeting 95 participants across 21 sites.
Detailed Summary
This study is trying to learn and understand if the chemotherapy drug called carboplatin works as well as the standard therapy. The standard therapy for Low Grade Glioma (LGG) in children and young adults is using a combination of carboplatin and vincristine. Studies in children have shown that the use of carboplatin alone has promise of being just as effective for treating LGG as standard therapy. Additionally, this study will try to understand if treatment with carboplatin alone is associated with an improved quality of life for LGG patients and their families.
Study Details
Timeline
Interventions
Carboplatin 175 mg/m2 IV infusion Vincristine 1.5mg/m2 IV
Carboplatin 560 mg/m2 (or 19 mg/kg for children weighing less than 12 kg) IV