At a glance
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The Dose-response Effects of D-allulose (Psicose) With Sucrose Beverage on Glucose Tolerance and Insulin Level in Healthy Volunteers and Volunteers With Impaired Fasting Glucose
In Brief
A clinical study evaluating D-allulose for Impaired Glucose Tolerance. Completed, enrolled 30 participants across 1 site.
Detailed Summary
Randomized, double-blind, crossover-trial, 30 subjects in each groups, either males or females, normal fasting glucose or pre-diabetes, aged \> 18 years old to perform oral sucrose tolerance with either one of the 5 study products 1. Sucrose 50 g 2. Sucrose 50 g + D-allulose (psicose) 2.5 g 3. Sucrose 50 g + D-allulose (psicose) 5 g 4. Sucrose 50 g + D-allulose (psicose) 7.5 g 5. Sucrose 50 g + D-allulose (psicose) 10 g Primary endpoints: 1. To investigate the dose-response effects of D- allulose (psicose) with sucrose beverage on glucose tolerance 2. To investigate the dose-response effects of D- allulose (psicose) with sucrose beverage on insulin levels
Study Details
Timeline
Interventions
Eligible subjects will come for visit 1 to consume varying dose of D-allulose with sucrose beverage with 1 of 5 beverages in a random order which will be blinded for both subjects and investigators. They will have to do 24-hour dietary record a day prior to each visit. Subjects have to be abstained from energy diet within 8 hours prior to each visit. Venous blood samples will be collected 6 mL for measurement of FPG and insulin before taking any study product. Subjects have to drink all within 1 minute. Blood samples will be drawn again 6 mL at 30, 60, 90 and 120 min after consumption for measurement of PG and insulin. Every subject will be asked to come back to finish OSTT with 5 study products in a random order, each at 7 days or \>5 days and \<12 days apart.