At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Validation of the Interaction Model of the Anesthetic Potency of Sevoflurane, Propofol and Remifentanil
In Brief
A Phase 4 clinical trial evaluating Propofol and Remifentanil, Sevoflurane and Remifentanil, and 2 other interventions for Drug Interactions and Anesthesia, Conduction. Completed, enrolled 172 participants across 1 site.
Detailed Summary
Recently a new model for the interaction of sevoflurane propofol and remifentanil was developed. The potency of any combination of the three drugs is defined as probability that a subject tolerates laryngoscopy without movement response. The model allows to compare the potency of intravenous and inhalation anesthetics. If the model is valid also for other stimuli than laryngoscopy and for other responses (e.g. blood pressure or heart rate increase upon stimulation). If the model is valid equipotent concentrations of sevoflurane and propofol the same remifentanil concentration would be sufficient to suppress hemodynamic response to a given stimulus. This will be investigated it the study.
Study Details
Timeline
Interventions
High propofol and low remifentanil, changing remifentanil (up-and-down method)
Low propofol and high remifentanil, changing propofol (up-and-down method)
High sevoflurane and low remifentanil, changing remifentanil (up-and-down method)
Low sevoflurane and high remifentanil, changing sevoflurane up-and-down method)
Triple combination with intermediate propofol and sevoflurane and intermediate remifentanil. SPR 1: Changing Propofol for skin incision.
Triple combination with intermediate propofol and sevoflurane and intermediate remifentanil. Changing Sevoflurane for skin incision.