CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 3,350 enrolled
Drug / intervention
Pantoprazole +1 moredrug
Likely dose
Pantoprazole 40 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02467621
NCT02467621Phase 4Completed
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Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU)

Dr. Morten Hylander Møller·interventional·Posted Jun 10, 2015·Updated May 19, 2026

In Brief

A Phase 4 clinical trial evaluating Pantoprazole and Saline (0.9%) for Gastrointestinal Bleeding and Stress Ulcers. Completed, enrolled 3,350 participants across 33 sites in 6 countries.

Detailed Summary

Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported. The aim of the SUP-ICU trial is to asses the overall benefits and harms of SUP with proton pump inhibitor in adult critically ill patients in the ICU.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGastrointestinal Bleeding, Stress Ulcers
CountriesDenmark, Finland, Netherlands, Norway, Switzerland, United Kingdom
CollaboratorsRigshospitalet, Denmark, Copenhagen Trial Unit, Center for Clinical Intervention Research

Timeline

Phase 4CompletedFinished
20162017201820192020202120222023202420252026
First PostedJun 10, 2015
Enrollment StartJan 1, 2016
Primary CompletionOct 22, 2017
Study CompletionJan 21, 2018
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 11.1 years ago

Interventions

Pantoprazoledrug

40 mg x 1 daily intravenously from ICU admission to ICU discharge

Saline (0.9%)other

10 ml of isotonic saline x 1 daily intravenously from ICU admission to ICU discharge