At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care
In Brief
A clinical study evaluating Remifentanil, Dexmedetomidine, and 3 other interventions for Fractures, Compression. Completed, enrolled 75 participants across 1 site.
Detailed Summary
This randomised, double-blind study compared remifentanil and dexmedetomidine for monitored anaesthesia care (MAC) during minimally invasive corrections of vertebral compression fracture (vertebroplasty (VP) and kyphoplasty (KP)). In total, 80 ASA physical status I-III patients scheduled for VP and KP randomly received remifentanil or dexmedetomidine to maintain OAA/S scale ≤ 4 during the procedures. Multiple hemodynamic variables of patients were recorded and the frequency of oxygen desaturation, respiratory depression, intraoperative need for other opioids, recovery time, operator satisfaction score, and patients' overall pain experiences were also compared. The investigators are expecting that both remifentanil and dexmedetomidine appear to be quite safe for MAC during VP and KP. Thus, dexmedetomidine may be an alternative for MAC during VP and KP in elderly patients.
Study Details
Timeline
Interventions
Patients given remifentanil received continuous infusion of the drug at 1-5 µg/kg/h
Patients receiving dexmedetomidine were given that drug at 0.3-0.4 µg/kg over 10 min, followed by continuous infusion of 0.2 1 µg/kg/h
All patients were premedicated with midazolam 0.02 mg/kg before induction.
All patients in both groups received a bolus dose of propofol 0.3 mg/kg for sedative effect.
Ephedrine 5 mg was injected when systolic blood pressure decreased below 90 mmHg