At a glance
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A Randomized Controlled Trial Investigating if Antibiotic Use in the First 48 Hours of Life Adversely Impacts the Preterm Infant Microbiome
In Brief
A clinical study evaluating Ampicillin, Gentamicins, and 1 other intervention for Premature Birth of Newborn and Enterocolitis, Necrotizing. Completed, enrolled 27 participants across 1 site.
Detailed Summary
The purpose of this study is to determine whether antibiotics given immediately after birth alter the development of the developing preterm infant's microbiome, which may further alter overall clinical outcomes.
Study Details
Timeline
Interventions
Ampicillin will be given as routine antibiotic coverage for those in the active arm, as the standard initial antibiotic used within the neonatal unit. It may also be used for patients who are not eligible for randomization.
Gentamicin will be given as routine antibiotic coverage for those in the active arm, as the standard initial antibiotic used within the neonatal unit. It may also be used for patients who are not eligible for randomization.
Normal saline will be given as placebo for those in the placebo comparator group.