At a glance
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Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects
In Brief
A Phase 2 clinical trial evaluating Ketamine, sirolimus, and 1 other intervention for Depression. Completed, enrolled 23 participants across 2 sites.
Detailed Summary
The aim of the study is to provide insight into the impact of the immunosuppressant drug sirolimus, on the antidepressant effects of the prototypal rapid-acting antidepressant medication, ketamine.
Study Details
Timeline
Interventions
. Subjects will receive an infusion of ketamine (0.5 mg/kg infusion over approximately 40 minutes). All subjects will receive two ketamine infusions-once with a placebo and once with a single dose of sirolimus (6 mg, oral administration).
Subjects will receive a single 6 mg oral dose via oral solution of sirolimus or a dose of placebo approximately two hours prior to the infusions. As above, the order of placebo and sirolimus is randomized. The sirolimus dose as well as the placebo solution will be given in 6 ounces of orange juice.
Placebo oral dose