At a glance
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Ectopy Triggering Ganglionated Plexus Ablation to Prevent Atrial Fibrillation
In Brief
A clinical study evaluating Pulmonary vein isolation and Ganglionated plexus ablation for Paroxysmal Atrial Fibrillation. Active but no longer recruiting, targeting 116 participants across 3 sites.
Detailed Summary
Atrial fibrillation (AF) is a common heart rhythm disorder which can significantly affect a patient's quality of life and cause strokes. Abnormal electrical activity from the pulmonary veins are thought to be the most common cause of this condition. Current ablative strategy in drug refractory AF is pulmonary vein isolation (PVI), where the pulmonary veins are electrically isolated from the body of the left atrium. However, success rate of this procedure remain \~50-70% for a single procedure despite advances in mapping and ablation techniques. Ganglionated plexuses (GP) are dense clusters of nerves in the atria that are implicated in AF. Endocardial high frequency stimulation (HFS) delivered within the local atrial refractory period can trigger ectopy and AF from specific GP sites (ET-GP). The aim of this study was to understand the role of ET-GP ablation in the treatment of AF by comparing two different strategies: 1. Pulmonary vein isolation alone 2. GP ablation alone
Study Details
Timeline
Interventions
Conventional endocardial radiofrequency catheter ablation for pulmonary vein isolation.
Endocardial radiofrequency catheter ablation of ganglionated plexus in the left atrium