At a glance
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A Pilot Study of MK-3475 With Cryotherapy for Men With Newly Diagnosed Oligo-metastatic Prostate Cancer
In Brief
A clinical study evaluating Cryosurgery, Degarelix, and 2 other interventions for Stage IV Prostate Cancer. Completed, enrolled 12 participants across 1 site.
Detailed Summary
This pilot phase II trial studies the side effects and how well pembrolizumab and cryosurgery work with short term androgen ablation to treat patients with prostate cancer that has traveled from the original tumor, through the body, and formed a small number of new tumors in other parts of the body (oligo-metastatic). Cryosurgery, also known as cryoablation or cryotherapy, kills tumor cells by freezing them. The process also incites an immune response within the ablated tumor. Giving monoclonal antibodies such as pembrolizumab which enhance a systemic anti-cancer immune response, may augment the effects of cryosurgery and increase tumor killing at distant (metastatic) sites.
Study Details
Timeline
Interventions
Undergo whole gland cryoablation
Given SC
Correlative studies
Given IV