CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 19 enrolled
Drug / intervention
Simvastatin (40mg) +2 moredrug
Likely dose
Simvastatin (40mg)from record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02490527
NCT02490527N/ACompleted
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Effects of Epicatechin on Patients With Statin-induced Mitochondrial Dysfunction and Impaired Exercise Capacity

University of California, San Diego·interventional·Posted Jul 7, 2015·Updated Sep 29, 2021

In Brief

A clinical study evaluating Pure epicatechin capsules (50mg), Simvastatin (40mg), and 1 other intervention for Statin Intolerance. Completed, enrolled 19 participants across 1 site.

Detailed Summary

The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes. The investigators' prior research has shown that epicatechin can improve skeletal muscle structure and mitochondrial (which gives us energy) structure.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStatin Intolerance
CountriesUnited States
CollaboratorsAmerican Heart Association

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedJul 7, 2015
Enrollment StartJun 1, 2015
Primary CompletionJul 28, 2021
TodayJul 2, 2026
Enrollment to primary: 6.2 yearsPosted 11.0 years ago

Interventions

Pure epicatechin capsules (50mg)dietary

Epicatechin is a compound found naturally in dark chocolate.

Simvastatin (40mg)drug

A cholesterol-lowering medication that blocks the production of cholesterol.

Placeboother

A substance that has no therapeutic effect and will act as a control.