At a glance
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Modulation of Long-term Memory by the Experience of Pain During Sedation With Anesthetics
In Brief
A Phase 1 clinical trial evaluating Dexmedetomidine, Midazolam, and 2 other interventions for Amnesia and 2 related conditions. Completed, enrolled 32 participants across 1 site.
Detailed Summary
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.
Study Details
Timeline
Interventions
Selected subjects received this drug during a portion of the study
Selected subjects received this drug during a portion of the study
Experimental acute pain stimulus was delivered using a nerve stimulator. These painful shocks were paired randomly with some of the auditory experimental cues.
Selected subjects received this drug during a portion of the study