At a glance

ClinicalIndex Comparison Record

N/ACompleted· 50 enrolled

Drug / intervention

Non invasive ventilation + High flow nasal cannula oxygen +1 moredevice

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02530957

NCT02530957N/ACompleted

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Comparison of Two Methods of Preoxygenation Before Oro Tracheal Intubation in the Hypoxemic Patient in Intensive Care Unit : Non Invasive Ventilation (NIV) + High Flow Nasal Cannula Oxygen Versus NIV Alone : a Randomized Controlled Study

University Hospital, Montpellier·interventional·Posted Aug 21, 2015·Updated Apr 10, 2017

In Brief

A clinical study evaluating Non invasive ventilation + High flow nasal cannula oxygen and Non invasive ventilation for Intubation Intraesophageal. Completed, enrolled 50 participants across 1 site.

Detailed Summary

Tracheal intubation is a challenging procedure in Intensive Care Unit (ICU), associated with severe life threatening complications. To decrease these complications, preoxygenation is recommended. Non invasive ventilation (NIV) increase effectiveness of preoxygenation, applying a positive end expiratory pressure (PEEP). High-flow nasal cannula oxygen (HFNC) improves oxygenation by increasing end-expiratory lung volume and has a potential of apneic oxygenation. The association of NIV and HFNC for preoxygenation in hypoxemic ICU patients has never been evaluated. The aim of this study is to determine if HFNC combined to NIV could have therapeutic advantages over NIV alone for preoxygenation in the ICU patients intubated for hypoxemic acute respiratory failure.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsIntubation Intraesophageal

CountriesFrance

Collaborators--

Timeline

N/ACompletedFinished

20162017201820192020202120222023202420252026

Enrollment StartJun 2015

First PostedAug 2015

Primary CompletionFeb 2016

Study CompletionMar 2016

TodayJul 2026

First PostedAug 21, 2015

Enrollment StartJun 23, 2015

Primary CompletionFeb 28, 2016

Study CompletionMar 17, 2016

TodayJul 2, 2026

Enrollment to primary: 8 monthsPosted 10.9 years ago

Interventions

Non invasive ventilation + High flow nasal cannula oxygendevice

In the interventional group, a preoxygenation by NIV (venturi mask of Intersurgical or Respironics mask) with PS of 10 cm H2O, PEEP of 5 cm H2O, FiO2 = 100% and combined to HNFC (nasal cannula oxygen of Fisher and Paykel) with Flow of 60L/min, FiO2 = 100% is applied.

Non invasive ventilationdevice

In the reference group, a preoxygenation by NIV (venturi mask of Intersurgical or Respironics mask) only, with PS of 10 cm H2O, PEEP of 5 cm H2O, FiO2 = 100% is applied.