At a glance
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The Effect of Remifentanil and Midazolam on Propofol for Loss of Consciousness During Induction of Anesthesia
In Brief
A clinical study evaluating Propofol, Remifentanil, and 1 other intervention for Anesthesia. Completed, enrolled 120 participants across 1 site.
Detailed Summary
Propofol in combination with remifentanil or midazolam can result in synergistic or additive effect. The patients who are scheduled to undergo general anesthesia are enrolled in this study. 120 patients will be randomly allocated to 3 groups(P, PR, PMR). The patients in group P will receive general anesthesia only with propofol and group PR and PMR will receive 0.25 mcg/kg/min remifentanil infusion prior to propofol. The patients in group PMR will receive 0.03 mg/kg bolus dose of midazolam 1 min after start of the remifentanil infusion. 'Success' is defined as loss of both verbal response and eyelash reflex in 2 min after propofol administration. When 'success', the next patient will receive the same dose(in 18/19 probability) or 0.25 mg/kg lower dose(in 1/19 probability) of propofol. When 'failure', the next patient will receive 0.25 mg/kg higher dose of propofol at induction period.
Study Details
Timeline
Interventions
Propofol bolus dose administration according to the predetermined dose by biased coined design up-and-down study.
Remifentanil 0.25 mcg/kg/min infusion for 5 min before propofol administration.
Remifentanil 0.25 mcg/kg/min infusion for 5 min before propofol administration followed by midazolam 0.03 mg/kg administration 1 min after remifentanil infusion start.