CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 336 enrolled
Drug / intervention
Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)drug
Likely dose
Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) 2 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02540954
NCT02540954Phase 3Completed

An Open-label, Randomized, Active-controlled, Parallel-group, Phase-3b Study of the Efficacy, Safety, and Tolerability of 2 mg Aflibercept Administered by Intravitreal Injections Using Two Different Treatment Regimens to Subjects With Neovascular Age-related Macular Degeneration (nAMD).

Bayer·interventional·Posted Sep 4, 2015·Updated Jun 11, 2021

In Brief

A Phase 3 clinical trial evaluating Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) for Macular Degeneration. Completed, enrolled 336 participants across 71 sites in 14 countries.

Detailed Summary

To compare the efficacy of 2 mg aflibercept administered by two different intravitreal (IVT) treatment regimens to subjects with neovascular age-related macular degeneration (nAMD)

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustria, Canada, Czechia, France, Germany, Hungary, Italy, Lithuania, Poland, Portugal, Slovakia, Spain, Switzerland, United Kingdom
Collaborators--

Timeline

Phase 3CompletedFinished
20162017201820192020202120222023202420252026
First PostedSep 4, 2015
Enrollment StartSep 29, 2015
Primary CompletionDec 24, 2019
Study CompletionJun 4, 2020
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 10.8 years ago

Interventions

Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)drug

A dose of 2 mg aflibercept injected intravitreally