CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 32 enrolled
Drug / intervention
Adaptive cardiac resynchronization therapy +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02543281
NCT02543281N/ACompleted

Adaptive CRT Effect on Electrical Dyssynchrony

Larisa Tereshchenko·interventional·Posted Sep 7, 2015·Updated Mar 20, 2025

In Brief

A clinical study evaluating Adaptive cardiac resynchronization therapy and Conventional Cardiac Resynchronization Therapy for Cardiomyopathy and 2 related conditions. Completed, enrolled 32 participants across 1 site.

Detailed Summary

The purpose of this study is to better understand how adaptive cardiac resynchronization therapy (aCRT) might benefit patients. aCRT works by sometimes giving stimulation to only the left side of the heart, rather than to both sides, depending on how it senses the heart is functioning. CRT without the adaptive algorithm works by giving stimulation to both sides of the heart. aCRT has already been approved by the FDA and is being used in patients now, but it is not clear which patients it should be used in compared to normal CRT. This study will include patients who are already scheduled to get a CRT device. The investigators will then randomize patients to the aCRT study arm or to the CRT study arm. After 6 months, the investigators will assess the electrical activity of the patients' hearts. After this time, the patient and their doctors will be able to decide if they would like to change the type CRT they have been designated.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedSep 7, 2015
Enrollment StartApr 1, 2015
Primary CompletionSep 1, 2021
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 10.8 years ago

Interventions

Adaptive cardiac resynchronization therapydevice

The adaptive cardiac resynchronization therapy (aCRT) algorithm works by sometimes giving stimulation to only the left side of the heart, rather than to both sides, depending on how it senses the heart is functioning.

Conventional Cardiac Resynchronization Therapydevice

CRT without the adaptive algorithm works by giving stimulation to both sides of the heart.