At a glance
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Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery in Adult Patients 60 Years of Age and Older
In Brief
A Phase 4 clinical trial evaluating IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine, and 2 other interventions for Delirium. Completed, enrolled 140 participants across 1 site.
Detailed Summary
Investigators will assess the incidence and duration of postoperative delirium in patients ≥60 years old undergoing coronary artery bypass grafting (CABG), with/without valve surgery (aortic and/or mitral) based on different regimens for postoperative sedation and analgesia. Patients will receive either intravenous (IV) dexmedetomidine and IV acetaminophen or standard postoperative management using IV propofol with morphine or hydromorphone. The Confusion Assessment Method (CAM) will be used to assess delirium in these patients. Investigators also seek to compare postoperative (48 hours) analgesic requirements in patients with or without IV acetaminophen. Investigators will finally assess postoperative cognition in post-surgical patients up to one year post-discharge using a cognitive assessment scale.
Study Details
Timeline
Interventions
use of IV tylenol and IV propofol for pain and sedation (respectively)
use of IV tylenol and IV dexmedetomidine for pain and sedation (respectively)
use of IV propofol for sedation and morphine, the drug of choice for cardiac pain
use of IV dexmedetomidine for sedation and morphine, the drug of choice for cardiac pain