At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Intra-oral Kinetics of Fluoride Containing Dentifrices in a Modified Saliva Clearance Study
In Brief
A clinical study evaluating Test Dentifrice, Reference Dentifrice, and 3 other interventions for Tooth Erosion. Completed, enrolled 29 participants across 1 site.
Detailed Summary
The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of fluoride and calcium ions in saliva over 60 minutes after a single brushing with US marketed fluoridated dentifrices and following a dietary acid challenge post 60 minutes of brushing with study treatment.
Study Details
Timeline
Interventions
Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3
Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3
Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3
Teeth will be rinsed with orange juice followed by rinsing with de-ionised water in test dentifrice and comparator dentifrice arms.
Teeth will be rinsed with de-ionised water followed by reference dentifrice and followed by rinsing with orange juice in test dentifrice and comparator dentifrice arms.