At a glance
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Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
In Brief
A Phase 2 clinical trial evaluating Metformin, Placebo, and 2 other interventions for Physical Activity. Completed, enrolled 56 participants across 1 site.
Detailed Summary
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program. In addition, the investigators propose that this stimulatory effect of protein feeding will overcome the potential blunting effect of metformin on exercise responses. The investigators will investigate these outcomes over a 12-week exercise-training program in older adults with pre-diabetes with or without metformin treatment.
Study Details
Timeline
Interventions
Daily administration of Metformin will begin as one 500 mg tablet for the first week and will increase by 500 mg/day/week until reaching 2000 mg/day by week 4 during a 12 week exercise training program.
Daily administration of matching placebo during a 12 week exercise training program.
Supervised aerobic exercise 3 days per week followed by a carbohydrate drink
Supervised aerobic exercise 3 days per week followed by a protein drink