At a glance
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Shortening of the Twitch Stabilization Period by Tetanic Stimulation in Acceleromyography in Children and Young Adults
In Brief
A Phase 4 clinical trial evaluating Tetanic stimulation and Staircase Stimulation for Train-of-Four-Monitoring. Completed, enrolled 80 participants across 1 site.
Detailed Summary
Repetitive nerve stimulation is used to monitor the neuromuscular transmission function in infants, children and adults after the application of muscle relaxants. During repetitive stimulation of a motor nerve, amplitude of contractions of the corresponding muscle will increase to a plateau (twitch potentiation), which is known as the staircase phenomenon. There is no systematic information about the staircase phenomenon of the adductor pollices muscle (ulnar nerve) in children between 1 month and 18 years . In adults , a 50-Hz tetanus administered before initial twitch stabilization is able to shorten the twitch stabilization period and to eliminate this staircase phenomenon. The purpose of this study is to investigate the characteristics of twitch potentiation in children between 1 month and 18 years by using acceleromyography. In addition we investigate whether application of a 50-Hz tetanic stimulation is able to eliminate the twitch potentiation like in adults.
Study Details
Timeline
Interventions
50 Hz tetanic stimulation before TOF-twitch stabilization with the aim to eliminate the staircase phenomenon
TOF-twitch stabilization without 50 Hz tetanic stimulation with the aim to verify the staircase phenomenon