At a glance
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Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients
In Brief
A Phase 3 clinical trial evaluating Methadone, Normal Saline, and 1 other intervention for Scoliosis and Pain. Completed, enrolled 58 participants across 1 site.
Detailed Summary
Acute pain management following major surgical procedures in pediatric patients continues to be a challenge, especially after extensive posterior spine fusions. Spine surgery is particularly traumatic, initiating pain in both peripheral and central pathways. While the standard management of post-surgical pain involves a multimodal approach, opioids provide the predominant benefit. However, opioid use is associated with many adverse effects, including nausea, constipation, and pruritus. Perioperative methadone may decrease total opioid consumption and adverse effects as well as improve satisfaction with pain management after scoliosis repair.
Study Details
Timeline
Interventions
Perioperative IV methadone to be given
control arm
Both groups will receive morphine via Patient-Controlled Analgesia (PCA) pump.