CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 40 enrolled
Drug / intervention
Sevoflurane +1 moredrug
Likely dose
Sevoflurane 10 mLfrom record
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Search/NCT02559297
NCT02559297Phase 2Completed
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Effects of Sevoflurane and Desflurane Anesthesia on Regulatory T Cells in Patients Undergoing Living Donor Kidney Transplantation

Mahidol University·interventional·Posted Sep 24, 2015·Updated Jun 15, 2017

In Brief

A Phase 2 clinical trial evaluating Sevoflurane and Desflurane for Transplant; Failure, Kidney. Completed, enrolled 40 participants across 1 site.

Detailed Summary

This prospective interventional study aims to compare sevoflurane and desflurane anesthetic agents on regulatory T cell (Treg) numbers and its cytokine production in patients undergoing Living Donor Kidney Transplant (LDKT).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTransplant; Failure, Kidney
CountriesThailand
Collaborators--

Timeline

Phase 2CompletedFinished
20162017201820192020202120222023202420252026
First PostedSep 24, 2015
Enrollment StartAug 10, 2015
Primary CompletionJun 3, 2017
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 10.8 years ago

Interventions

Sevofluranedrug

After induction of anesthesia and successful intubation, 2 L/min N2O, 2 L/min O2 , and 2% to 2.5% sevoflurane will be given for 10 minutes then total flow will be decreased to 2 L/min. Anesthesia will be maintained using 1-1.5 minimal alveolar concentration (MAC) of sevoflurane in 50% O2 and 50% N2O. Ventilation will be adjusted to keep end-tidal carbon dioxide 30-35 mmHg (Tidal volume 7-10 mL/kg).

Desfluranedrug

After induction of anesthesia and successful intubation, 2 L/min N2O, 2 L/min O2 , and 6% to 8% desflurane will be given for 10 minutes then total flow will be decreased to 2 L/min. Anesthesia will be maintained using 1-1.5 minimal alveolar concentration (MAC) of desflurane in 50% O2 and 50% N2O. Ventilation will be adjusted to keep end-tidal carbon dioxide 30-35 mmHg (Tidal volume 7-10 mL/kg).