At a glance
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Influence of Apelin Levels on Postoperative Cognitive Disorders After Orthopedic Surgery in Elderlies
In Brief
A clinical study evaluating Determination of apelin and inflammatory cytokines, Assessment of cognitive functions, and 3 other interventions for Delirium. Completed, enrolled 88 participants across 1 site.
Detailed Summary
No successful strategy is proposed to patients submitted to important surgery to reduce the incidence of postoperative cognitive disorders (POCD) onset. This project propose to measure plasma levels of apelin in wide population submitted to orthopedic surgery. Apelin could be involved in anti-inflammatory processes. Apelin levels before and after surgery correlated to postoperative cognitive disorders symptom measured by PET-Scan could be an important predictive or diagnostic marker to adapt therapeutic strategy to fight against postoperative cognitive disorders.
Study Details
Timeline
Interventions
A blood sample will be conducted at baseline, on day 1 and day 7 post operative to meter inflammatory cytokines (IL1B, IL1-ra, IL6) and apelin.
Evaluation of preoperative cognitive performance by achieving a IQCODE, an MMS and an IADL scale.
Determination of the concentrations of inflammatory cytokines and apelin in cerebrospinal fluid perioperatively.
Using the scale Confusion Assessment Method (CAM) for screening and delirium diagnosis. This research will be daily lasted, during the first 7 days postoperative.
Evaluation of postoperative cognitive performance by achieving a IQCODE, an MMS and an IADL scale realised on day 1 and day 7 postoperative. Realization of the IQCODE and IADL three months after the operation in a telephone interview.