At a glance
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Elucidation of the Influence of Sleep Apnea on Risk of Atrial Fibrillation
In Brief
A clinical study evaluating Continuous Positive Airway Pressure for Sleep Apnea and Atrial Fibrillation. Completed, enrolled 317 participants across 1 site.
Detailed Summary
The Elucidation of the Influence of Sleep Apnea on Risk of Atrial Fibrillation study. The study involves a case control design to investigate the extent to which there is an independent relationship of sleep disordered breathing (SDB) and paroxysmal atrial fibrillation (PAF). Cases will be defined as clinically identified patients with PAF and controls as those without AF. In order to rigorously address important biologic confounding influences, the cases and controls will be individually matched based upon age, gender, race, and body mass index. Those participants with both PAF and SDB (Apnea Hypopnea Index, AHI\>=15) will be asked to return for a follow up exam after 3 months of SDB treatment in the Clinical Research Unit (CRU) for collection of the same measures collected at the baseline exam to observe for any significant changes with the purpose of collecting effect size data to inform future clinical trials. The total duration of the study is 4 years. The duration for any individual participant is up to from one to 13 weeks months, including a 3-month treatment period for those with moderate to severe SDB, i.e. AHI\>15.
Study Details
Timeline
Interventions
For cases, those found to have moderate sleep apnea (AHI \>=15) will be place on CPAP therapy.