CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
Calcium Chloride/Calcium Gluconate +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02580604
NCT02580604N/ACompleted
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PTH And Calcium Responses to Exercise in Older Adults Experiment 2 (PACE Sr. 2)

University of Colorado, Denver·interventional·Posted Oct 20, 2015·Updated Aug 13, 2025

In Brief

A clinical study evaluating Calcium Chloride/Calcium Gluconate and Half-Normal Saline for Osteoporosis. Completed, enrolled 12 participants across 1 site.

Detailed Summary

Declines in serum calcium during exercise may cause increases in markers of bone resorption. This study will determine if preventing the decline serum ionized calcium experienced at the onset of exercise through the use of a "calcium clamp" also prevents increases in blood biomarkers associated with bone resorption.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOsteoporosis
CountriesUnited States
CollaboratorsNational Center for Advancing Translational Sciences (NCATS)

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedOct 20, 2015
Enrollment StartNov 1, 2015
Primary CompletionJul 31, 2024
Study CompletionJul 31, 2025
TodayJul 2, 2026
Enrollment to primary: 8.8 yearsPosted 10.7 years ago

Interventions

Calcium Chloride/Calcium Gluconatedrug

Calcium (as either calcium chloride or calcium gluconate in half normal saline) will be delivered via IV during exercise to keep serum ionized calcium levels above baseline. The clamp is modeled after the hyperglycemic glucose clamp.

Half-Normal Salinedrug

This is the placebo comparative infusion. Half-normal saline will be infused at the second collection visit following the identical infusion schedule determined during the calcium infusion visit.