At a glance
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Peripheral Chemoreflex/Arterial Baroreflex Interaction in Patients With Electrical Carotid Sinus Stimulation
In Brief
A clinical study evaluating Hypoxia without dopamine, Hypoxia with dopamine, and 2 other interventions for Hypertension, Resistant to Conventional Therapy. Completed, enrolled 11 participants across 1 site.
Detailed Summary
Peripheral chemoreceptors and baroreceptors are located in close proximity in the carotid artery wall at the level of the carotid bifurcation. Baroreceptor stimulation lowers sympathetic activity and blood pressure. In contrast, chemoreceptor stimulation raises sympathetic activity and blood pressure. Thus, beneficial effects of electrical carotid sinus stimulation on blood pressure could be diminished by chemoreceptor overactivity and/or concomitant chemoreceptor activation through the device. Therefore, our study will assess baroreflex/chemoreflex interactions in patients with resistant hypertension equipped with carotid sinus stimulators. The study will inform us of potential additional anti-hypertensive benefits of simultaneous chemoreceptor denervation during electrode placement. Furthermore, the results may provide information about suitable electrode design to spare co-activation of peripheral chemoreceptors. Taken together, the study will help develop strategies for improving responder rate and efficacy of carotid sinus stimulators in patients with resistant hypertension.
Study Details
Timeline
Interventions
Target hemoglobin oxygen saturation (SpO2) 80%.
Target hemoglobin oxygen saturation (SpO2) 80%. Dopamine dose 3 µg/kg/min.
Nearly complete hemoglobin oxygen saturation.
Nearly complete hemoglobin oxygen saturation. Dopamine dose 3 µg/kg/min.