At a glance
ClinicalIndex Comparison Record- ✓Age 18–64 years
- ✓Confirmed HIV-1 infection with subtype A, B, C, D, CRF01_AE, or CRF02_AG
- ✓On ART for ≥2 years with no regimen changes for ≥90 days before entry
- ✓CD4 T-cell count ≥500/μl for ≥3 months prior to entry
- ✕Prior or current AIDS-defining event (CDC category C)
- ✕Acute infection or serious illness within 60 days of entry
- ✕History of antiretroviral drug resistance by genotype
- ✕Active hepatitis B or C infection with viral replication
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Analytical Treatment Interruption in HIV Positive Patients With Low Viral Reservoir to Evaluate the Potential of a Functional Cure
In Brief
A clinical study evaluating ART interruption for HIV-1 Infection. Completed, enrolled 114 participants across 4 sites.
Detailed Summary
HIV-1 infected patients with normal peripheral blood CD4+ T-cell counts and undetectable viral load will be recruited in four Belgian HIV reference centers. Selected patients will undergo a two-step screening in which a viral reservoir measurement will be performed and among those with a very low viral reservoir an analytical treatment interruption of their longstanding antiretroviral therapy (ART). There is no randomization foreseen. Patients will receive an intense clinical and laboratory follow-up during 48 weeks followed by 12 weeks post intervention.