CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 21 enrolled
Drug / intervention
Phenytoin 200 mg capsule +3 moredrug
Likely dose
Phenytoin 200 mg capsulefrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02595723
NCT02595723Phase 4Completed
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Phenytoin for Memory Impairment Secondary to Megestrol

University of Texas Southwestern Medical Center·interventional·Posted Nov 3, 2015·Updated Sep 9, 2019

In Brief

A Phase 4 clinical trial evaluating Phenytoin 200 mg capsule, Megestrol 800 mg liquid, and 2 other interventions for Cognitive Impairment. Completed, enrolled 21 participants across 1 site.

Detailed Summary

This study is designed to test if megestrol acetate induces changes in declarative memory in healthy controls and if pre-administration of phenytoin can ameliorate any induced cognitive impairments.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCognitive Impairment
CountriesUnited States
CollaboratorsThe Rogosin Institute

Timeline

Phase 4CompletedFinished
20162017201820192020202120222023202420252026
First PostedNov 3, 2015
Enrollment StartJul 1, 2015
Primary CompletionNov 1, 2016
Study CompletionDec 1, 2016
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 10.7 years ago

Interventions

Phenytoin 200 mg capsuledrug

Phenytoin oral capsule was initiated on Day 1 and administered at 200 mg twice/day for four consecutive days (Days 1 - 4).

Megestrol 800 mg liquiddrug

Liquid megestrol 800 mg/was initiated on Day 2 and administered at 09:00 for three consecutive days (Days 2 - 4).

Phenytoin-matched Placebo capsuledrug

Phenytoin-matched oral Placebo capsule was initiated on Day 1 and administered for four consecutive days (Days 1 - 4).

Megestrol-matched liquid Placebodrug

Megestrol-matched liquid placebo was initiated on Day 2 and administered at 09:00 for three consecutive days (Days 2 - 4).