At a glance
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The Effect of Glutamatergic Modulation on Cocaine Self-administration
In Brief
A Phase 2 clinical trial evaluating CI-581a and CI-581b for Cocaine Dependence. Completed, enrolled 18 participants.
Detailed Summary
Repeated drug consumption may progress to problematic use by triggering neuroplastic adaptations that attenuate sensitivity to natural rewards while increasing reactivity to craving and drug cues. Converging evidence suggests that glutamate modulation may work to correct these adaptations and rapidly restore motivation for delayed non-drug rewards relative to immediate drug use. Using an established laboratory model aimed at evaluating behavioral shifts in the salience of cocaine now vs. money later, the investigators will test the effect of CI-581a on cocaine self-administration as compared to the active control.
Study Details
Timeline
Interventions
a 50 minute infusion 24 hours prior to cocaine self-administration session
a 50 minute infusion 24 hours prior to cocaine self-administration session