At a glance
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The Use of Agitated Saline, Albumin, or a Propofol-albumin Mixture for Enhanced Contrast in Bubble Studies During Transesophageal Echocardiographic Examinations
In Brief
A clinical study evaluating normal saline, human albumin, and 1 other intervention for Transesophageal Echocardiography Contrast Agents. Completed, enrolled 17 participants across 1 site.
Detailed Summary
This is a prospective, randomized, controlled study to determine if albumin and propofol or albumin only will provide superior qualitative contrast enhancement during TEE bubble studies compared to agitated saline. Each patient will receive three randomized bubble studies (agitated saline, albumin, and albumin and propofol) using 10 ml of agitated contrast agent. The albumin and propofol mixture will consist of 7 mL of 5% albumin plus 3 mL of propofol (10 mg/mL). Each patient will undergo qualitative review of all 3 bubble studies by 10 different anesthesiologists and/or cardiologists credentialed to read echocardiographic studies at the time of the surgical procedure, and also with retrospective review of the echo video (\~200 studies). A bicaval view will be obtained to record a 20 beat loop for each bubble study. Hemodynamic variables prior to injection of contrast agent; and 30 seconds, 1 minute and 2 minutes after injection will be monitored and recorded.
Study Details
Timeline
Interventions
10 mL of normal saline agitated prior to IV administration
10 mL of 5% albumin agitated prior to IV administration
7 mL of 5% albumin mixed with 3 mL of propofol (10 mg/mL) agitated together prior to IV administration