At a glance
ClinicalIndex Comparison RecordN/ACompleted· 125 enrolled
Drug / intervention
Not specified
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Prospective Observational Trial Evaluating Outcomes of FoundationOne - Directed Matched Targeted Therapy in Patients With Cancer of Unknown Primary (CUP)
In Brief
An observational study for Neoplasms, Unknown Primary and 5 related conditions. Completed, enrolled 125 participants across 1 site.
Detailed Summary
The goal of the current study is to determine whether Foundation Medicine's next generation sequencing assay, called FoundationOne, will provide information that allows physicians to make treatment decisions using targeted therapies in clinical trials or FDA approved therapies, including "off-label" agents, that result in superior OS compared to historical outcomes for standard CUP therapy.
Study Details
Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsNeoplasms, Unknown Primary, CUP, Metastatic Disease, Poorly Differentiated Adenocarcinoma, Poorly Differentiated Carcinoma, Squamous Carcinoma Poorly Differentiated
CountriesUnited States
CollaboratorsRush University Medical Center, Stormont-Vail Healthcare, Jefferson Medical College of Thomas Jefferson University, The Cleveland Clinic, Sparrow Health System, Cancer & Hematology Centers of Western Michigan (CHCWM), Allegheny Health Network, St. Luke's Hospital and Health Network, Pennsylvania, Solano Hematology Oncology, Horizon Oncology Center, Comprehensive Blood and Cancer Center, Lancaster Cancer Center, Western Maryland Health Center, Valley Medical Oncology, Cape Fear Valley Health System, Tri-County Hematology Oncology, Hematology & Oncology Associates, Broome Oncology, Orchard Healthcare, Ashland Bellefonte Cancer Center, Tennessee Cancer Specialists, North Shore Hematology Oncology, Good Samaritan, Zangmeister Cancer Center, Watson clinic, Oncology Consultants, Oncology Hematology Care, Northern Westchester Hospital, Peter MacCallum Cancer Center Trials Unit
Timeline
N/ACompletedFinished
20162017201820192020202120222023202420252026
Enrollment StartMay 2015
First PostedDec 2015
Primary CompletionMar 2017
TodayJul 2026
First PostedDec 11, 2015
Enrollment StartMay 1, 2015
Primary CompletionMar 1, 2017
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 10.6 years ago