CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 19 enrolled
Drug / intervention
Placebos +1 moredrug
Likely dose
Metformin dose not specified in trial recordAI-extracted
Key inclusion· 4
  • ✓Age 18–60 years
  • ✓No smoking for past 6 months
  • ✓Must have 3 of 4 metabolic syndrome features per NCEP-AHA-NHLBI: abdominal obesity (waist >40 in males, >35 in females), BP >130/85 or on antihypertensive, fasting triglycerides >150 or HDL <40 (males)/<50 (females), or fasting glucose >100 but <126
  • ✓Normal screening labs (except metabolic syndrome markers)
Key exclusion· 10
  • ✕Current smoker or smoked within past 6 months
  • ✕HbA1c ≥6.5% (indicates diabetes)
  • ✕History of diabetes or other metabolic disorders
  • ✕Known hypersensitivity or intolerance to metformin

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02633488
NCT02633488N/ACompleted
CompareCT.gov

Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome

University of Virginia·interventional·Posted Dec 17, 2015·Updated Mar 23, 2020

In Brief

A clinical study evaluating Placebos and metformin for Metabolic Syndrome and Insulin Sensitivity. Completed, enrolled 19 participants across 1 site.

Detailed Summary

The purpose of this study is to look at how insulin (a hormone that helps the cells get energy from sugar) in our body affects blood vessels (elasticity in the bigger blood vessels and blood flow in the smaller blood vessels in the arm) and how Metformin (a drug that makes you more sensitive to insulin) affects insulin's action on the blood vessels.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMetabolic Syndrome, Insulin Sensitivity
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedDec 17, 2015
Enrollment StartJun 1, 2014
Primary CompletionJul 1, 2016
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 10.5 years ago

Interventions

Placebosdrug

A 12 week single blind placebos

metformindrug

A 12 week single blind metformin