CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 248 enrolled
Drug / intervention
(dexlan+amox+clar+metr)+(dexlan+amox) +1 moredrug
Likely dose
Reverse hybrid: dexlansoprazole MR 60 mg once daily, amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, metronidazole 500 mg twice daily for 7 days, followed by dexlansoprazole MR 60 mg once daily and amoxicillin 1 g twice daily for 7 days. Concomitant: dexlansoprazole MR 60 mg once daily, amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, metronidazole 500 mg twice daily for 14 days.AI-extracted
Key inclusion· 3
  • ✓Age at least 20 years
  • ✓H. pylori infection confirmed by endoscopy
  • ✓Endoscopically proven peptic ulcer disease or gastritis
Key exclusion· 6
  • ✕Prior H. pylori eradication therapy
  • ✕Antibiotics or bismuth within prior 4 weeks
  • ✕Allergy to study medications
  • ✕Prior gastric surgery

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02646332
NCT02646332N/ACompleted
CompareCT.gov

Comparing the Efficacy and Impact on Gastrointestinal Microbiota of Reverse Hybrid Therapy and Concomitant Therapy in Helicobacter Pylori Eradication

Kaohsiung Veterans General Hospital.·interventional·Posted Jan 5, 2016·Updated Nov 24, 2020

In Brief

A clinical study evaluating (dexlan+amox+clar+metr)+(dexlan+amox) and dexlan+clarith+amox+metro for Helicobacter Pylori Infection. Completed, enrolled 248 participants across 1 site.

Detailed Summary

Reverse hybrid therapy achieves a higher eradication rate than concomitant therapy remains unanswered.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHelicobacter Pylori Infection
CountriesTaiwan
Collaborators--

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedJan 5, 2016
Enrollment StartDec 1, 2015
Primary CompletionJul 31, 2020
Study CompletionAug 31, 2020
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 10.5 years ago

Interventions

(dexlan+amox+clar+metr)+(dexlan+amox)drug

a 7-day quadruple regimen with dexlansoprazole MR 60 mg once daily, amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, and metronidazole 500 mg twice daily, followed by a 7-day dual regimen with dexlansoprazole MR 60 mg once daily and amoxicillin 1 g twice daily

dexlan+clarith+amox+metrodrug

dexlansoprazole MR 60 mg once daily, amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily, and metronidazole 500 mg twice daily for 14 days