At a glance
ClinicalIndex Comparison Record- ✓Low back pain duration of 2 weeks or less
- ✓No trauma to the low back in the previous month
- ✓No radicular (nerve root) symptoms
- ✓No history of chronic low back pain or only infrequent prior episodes
- ✕Known allergies or contraindications to study medications
- ✕Unable to complete follow-up visits
- ✕Chronic pain syndrome diagnosis
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Methocarbamol and Orphenadrine for Acute, Non-traumatic, Non-radicular Low Back Pain: A Randomized, Placebo Controlled, 3-armed Study
In Brief
A Phase 4 clinical trial evaluating Orphenadrine, Methocarbamol, and 2 other interventions for Low Back Pain. Completed, enrolled 240 participants across 1 site.
Detailed Summary
Low back pain is a common cause of visit to emergency department. It is not clear if skeletal muscle relaxants are of benefit for patients with acute low back pain. This is a randomized study to determine if skeletal muscle relaxants, when combined with naproxen, improve outcomes more than naproxen alone
Study Details
Timeline
Interventions
Orphenadrine 100mg PO BID x 7 days
Methocarbamol 750mg 1-2 tabs po TID x 7 days
Naproxen 500mg PO BID x 7 days
1/2 of placebo packages will be dosed to match methocarbamol: 1-2 tabs po TID x 7days 1/2 of placebo packages will be dosed to match orphenadrine: 1 tab PO BID x 7 days