CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 110 enrolled
Drug / intervention
Etomidate +2 moredrug
Likely dose
Etomidate 0.2mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02667353
NCT02667353N/ACompleted
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Structural Brain Plasticity in Elderly Depressed Patients Following Electroconvulsive Therapy

Universitaire Ziekenhuizen KU Leuven·interventional·Posted Jan 28, 2016·Updated Jan 28, 2016

In Brief

A clinical study evaluating ECT, Etomidate, and 1 other intervention for Depression. Completed, enrolled 110 participants.

Detailed Summary

To study the potential neurorestorative effects of electroconvulsive therapy (ECT) in depressed patients by measuring brain derived neurotrophic factor (BDNF) serum levels and hippocampal volumes in severely depressed patients receiving ECT.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
Countries--
CollaboratorsVU University of Amsterdam

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJan 28, 2016
Enrollment StartJun 1, 2011
Primary CompletionJun 1, 2014
Study CompletionDec 1, 2015
TodayJul 2, 2026
Enrollment to primary: 3 yearsPosted 10.4 years ago

Interventions

ECTprocedure

ECT was administered twice a week with a constant-current brief-pulse device (Thymatron, System IV). Motor and electroencephalographic seizures were monitored to ensure adequate duration and quality. Subjects were all treated with right unilateral (RUL) ECT with stimulus intensity 6 times the initial seizure threshold (ST), as determined by empirical dose titration at the first treatment, until remission (Montgomery-Åsberg Depression Rating Scale (MADRS) (27) \< 10 in two consecutive ratings with a week interval). Subjects who failed to respond right unilateral ECT after the sixth treatment were switched to bitemporal ECT (1.5x seizure threshold).

Etomidatedrug

Anesthesia was achieved with intravenous administration of etomidate (0.2mg/kg).

Succinylcholinedrug

Anesthesia was achieved with intravenous administration of succinylcholine (1mg/kg).